Patient-Derived Xenograft (PDX) Metal Needle

PDX method and application

The tumor fragments harvested from the patient can be transplanted into the flanks or into particular organs of the immunocompromised mice that are maintained under controlled laboratory conditions and carefully monitored (Miles et al, 2014). The immune deficiencies of the laboratory mice enhance the formation of xenografts that have the unique features of the engrafted tumor and allow the optimization of the specific therapy. The xenografts derived from human tumours can also be analysed in order to identify their special characters, the mutations that affect them and the influence of certain factors on the gene expression.